Bioengineering (BIOE)

Courses

BIOE 0844. The Bionic Human. 3 Credit Hours.

Can we replace our "worn-out" body parts with space-age materials? Will the day come when an injured athlete buys a tendon for the next big game? Why are your parents spending so much time at the doctor? We are on the verge of building "the bionic human" by repairing many of our body parts indefinitely. Become familiar with bio-engineered technologies for age-, disease-, sports-, and accident-related injuries. Learn why weight bearing exercise strengthens bones, the difference between MRI, CAT scan, and X-Ray, and what the folks at the Food and Drug Administration do. By the time you finish this course, you'll know how a pig heart could save your life, how stem cell research could affect your future, the purpose of animal testing, and why walking through airport security could be a problem if you have had your hip replaced. NOTE: This course fulfills a Science & Technology (GS) requirement for students under GenEd and Science & Technology Second Level (SB) for students under Core. Students cannot receive credit for this course if they have successfully completed BIOE 0944, MEE 0844, or MEE 0944.

Course Attributes: GS

Repeatability: This course may not be repeated for additional credits.

BIOE 0856. Ethical Issues in Biomedical Science, Engineering and Technology. 3 Credit Hours.

At some point in our lives, each of us will be confronted with difficult biomedical and biotechnological questions that present an ethical dilemma. This course is designed to enable you to critically address important issues in ethics that arise from advances in these fields. We will consider potential advantages of using modern technologies to improve human health, in contrast to the risks associated with their application. Some of the questions we will pose include: Is it acceptable to use technology to restore our bodies to a pre-injury state? If so, what about using technology to enhance our bodies to improve our performance? What are the implications of the use of reproductive technology that results in one child having three biological parents? Can a physician text a picture of an X-ray to another colleague? These questions, and many others, will be explored in detail through class and small group discussions, coupled with analysis of current news events and scientific publications. Evidence-based approaches will be used to investigate issues related to a variety of subjects including use/overuse of imaging modalities, organ transplant, regenerative tissue engineering and medicine, human enhancements, genetic engineering, personalized medicine, reproductive control (e.g. IVF, surrogate pregnancy), cloning, stem cell use, medical privacy in the era of the electronic medical record, texting, and Instagram, and animal testing for cosmetics, drugs, or medical devices.

Course Attributes: GS

Repeatability: This course may not be repeated for additional credits.

BIOE 0944. Honors Bionic Human. 3 Credit Hours.

From MRIs to engineered organs, modern healthcare has become synonymous with applications of bioengineering and technology. This course focuses on the new bioengineering paradigm, exploring the ways in which disciplines intersect to produce advances in healthcare. A key goal is to enable students to make more informed decisions about healthcare based on their understanding not only of technological advancements but of the ethical and societal issues arising as a consequence. This discovery-based seminar includes interactive lectures, hands-on and virtual labs, discussion, research and presentations. NOTE: This course fulfills a Science & Technology (GS) requirement for students under GenEd and Science & Technology Second Level (SB) for students under Core. Students cannot receive credit for this course if they have successfully completed BIOE 0844, MEE 0844, or MEE 0944.

Cohort Restrictions: Must be enrolled in one of the following Cohorts: SCHONORS, UHONORS, UHONORSTR.

Course Attributes: GS, HO

Repeatability: This course may not be repeated for additional credits.

BIOE 2001. Frontiers in Bioengineering. 2 Credit Hours.

This survey course will provide a first introduction to the wide scope of biomedical engineering, with emphasis on the application of engineering principles to solving problems in biology and medicine. Specific topics will include biomechanics; bioimaging; bioinstrumentation and biomedical devices; artificial organs; computational biology and bioinformatics; biomaterials and drug delivery; cellular, tissue and regenerative engineering; and nanobiotechnology. At the end of this introductory course the students will be familiar with some of the major molecular, cellular, physiological and engineering principles that allow for problem solving in the vast area of biomedical engineering. Thus the students will be prepared to study in depth some of the specialized topics of bioengineering.

Repeatability: This course may not be repeated for additional credits.

BIOE 2101. Engineering Principles of Physiological Systems. 3 Credit Hours.

This course will introduce biomedical engineering students to quantitative modeling of physiological systems. It will cover fundamental topics in physiology ranging from cell membrane models and chemical messengers to neuronal signaling and control of body movement. In addition, specific physiological systems are discussed in detail, including the cardiovascular, pulmonary, and visual systems. Furthermore, pharmacokinetic models provide quantitative assessment of the dynamics of drug distribution and compartmental interactions. Hands-on laboratories combining actual experiments with computer simulations will reinforce the contents of classroom teaching.

Department Restrictions: Must be enrolled in one of the following Departments: Engineering:Bio Engineering.
Field of Study Restrictions: Must be enrolled in one of the following Fields of study: Bioengineering.

Repeatability: This course may not be repeated for additional credits.

Pre-requisites: Minimum grade of C- in (BIOL 2112 (may be taken concurrently), BIOL 1012 (may be taken concurrently), BIOL 2912 (may be taken concurrently), or 'Y' in BIOW)

BIOE 2301. Quantitative Pathophysiology. 3 Credit Hours.

This course will introduce students to fundamental principles of human pathophysiology. Students will gain a systems level understanding of disease processes necessary for the rational design of novel therapeutic and diagnostic technologies. The course will integrate basic biological science and fundamental engineering principles in the evaluation of clinical disease manifestations. Topics that will be covered include: fundamental concepts of cellular homeostasis; cellular responses (adaptation, injury, cell death) induced by stress, injurious stimuli, and disease, and systemic models of major diseases within the US (cardiac, neoplastic, cerebrovascular, traumatic, neurodegenerative, diabetic, and pulmonary).

Department Restrictions: Must be enrolled in one of the following Departments: Engineering:Bio Engineering.
Field of Study Restrictions: Must be enrolled in one of the following Majors: Bioengineering.

Repeatability: This course may not be repeated for additional credits.

Pre-requisites: Minimum grade of C- in BIOE 2101.

BIOE 2302. Cellular and Molecular Biology for Bioengineers. 3 Credit Hours.

This course will enhance the basic knowledge of the students in quantitative cell and molecular biology from the vantage point of a bioengineer, focusing on molecular mechanisms and cellular functions, specifically in cell-cell and cell-matrix communications. Textbook learning will be supplemented with results from recent research and technological innovations in biology. After completing this course, bioengineering students will be able to apply their aptitude in the quantitative, physical and engineering sciences to modern biology. Students will also learn the principles how to establish and test biological models.

Department Restrictions: Must be enrolled in one of the following Departments: Engineering:Bio Engineering.
Field of Study Restrictions: Must be enrolled in one of the following Majors: Bioengineering.

Repeatability: This course may not be repeated for additional credits.

Pre-requisites: Minimum grade of C- in BIOE 2101.

BIOE 2312. Mechanics for Bioengineering I. 4 Credit Hours.

This course will provide students with an understanding of the application of statics and strength of materials to biomechanical problem analyses. Topics will introduce basic concepts of mechanics and kinetic analyses with application to physiologic loading and motion in the body.

Department Restrictions: Must be enrolled in one of the following Departments: Engineering:Bio Engineering.
Field of Study Restrictions: Must be enrolled in one of the following Majors: Bioengineering.

Repeatability: This course may not be repeated for additional credits.

Pre-requisites: Minimum grade of C- in (PHYS 1062 (may be taken concurrently), PHYS 1962 (may be taken concurrently), PHYS 2022 (may be taken concurrently), or PHYS 2922 (may be taken concurrently)) and (MATH 1042, MATH 1942, or 'Y' in MATW)

BIOE 2401. Biodesign - Needs and Ideation. 3 Credit Hours.

This course will incorporate the 5-steps of the Design Thinking process in a project-based learning (PBL) environment focusing on bioengineering-specific projects. During these open-ended projects, the students will work in small teams that will 1) delve deeply into the development of the problem statements and needs criteria, 2) ideation process, 3) designing potential solutions, 4) proof of concept, and 5) move on to designing and creating prototypes and writing up the supporting documentation.

Repeatability: This course may not be repeated for additional credits.

Pre-requisites: Minimum grade of C- in (MATH 1042 or 'Y' in MATW), (PHYS 1062 or PHYS 2022), and ENGR 1101.

BIOE 3001. Research Design and Methods in Bioengineering. 2 Credit Hours.

In this course the upper division students will learn how to integrate fundamental principles of biology, chemistry, engineering, mathematics (including statistics) and physics to develop practical solutions for a variety of biomedical problems from cells to organisms. Students will use both engineering (methodology) and scientific (hypothesis) approaches to problem-solving thereby learning to distinguish between the two approaches. This course will teach the students the fundamental principles underlying modern measurements and control instrumentation utilized in science and engineering. Taking a quantitative and hands-on approach to measurement theory and practice, this course will present and analyze example instruments currently used in academic and industrial research. In addition, the students will consider and discuss bioethical issues involving biological and living systems. Specific bioethics topics that will be covered include stem cells, patents, conflict of interest, patient rights, animal rights, organ donation, and data manipulations but are not limited to them.

Department Restrictions: Must be enrolled in one of the following Departments: Engineering:Bio Engineering.
Field of Study Restrictions: Must be enrolled in one of the following Majors: Bioengineering.

Repeatability: This course may not be repeated for additional credits.

Pre-requisites: Minimum grade of C- in (MATH 1041, MATH 1941, MATH 1038, or 'Y' in MATW) and (CHEM 1031 or CHEM 1951)

BIOE 3101. BioE Lab #1 - Bioelectrical Engineering. 3 Credit Hours.

This laboratory class will introduce students to the empirical study of bioelectric phenomena in physiological systems. This includes the origin of biopotentials, the use of biopotential electrodes in their measurements and subsequent amplification, signal processing and analysis of their physiological relevance. Applications of physical principles and basic electric engineering techniques are emphasized.

Department Restrictions: Must be enrolled in one of the following Departments: Engineering:Bio Engineering.
Field of Study Restrictions: Must be enrolled in one of the following Majors: Bioengineering.

Repeatability: This course may not be repeated for additional credits.

Pre-requisites: Minimum grade of C- in BIOE 3201 (may be taken concurrently), (PHYS 1062 or PHYS 2022), (MATH 1042, MATH 1942, or 'Y' in MATW), and BIOE 2001 (may be taken concurrently)

BIOE 3102. BioE Lab #2 - Biomaterials. 3 Credit Hours.

This laboratory class will teach students experimental methods used to prepare and characterize biomaterials used in biomedical engineering. Students will learn basic techniques for the fabrication and characterization tools used for polymeric biomaterials, and investigate structure-property relationships as it applies to thermal, mechanical, surface and morphological properties of polymeric biomaterials.

Department Restrictions: Must be enrolled in one of the following Departments: Engineering:Bio Engineering.
Field of Study Restrictions: Must be enrolled in one of the following Majors: Bioengineering.

Repeatability: This course may not be repeated for additional credits.

Pre-requisites: Minimum grade of C- in BIOE 2101 (may be taken concurrently) and BIOE 3001.

BIOE 3201. Biomedical Instrumentation. 2 Credit Hours.

This course will introduce the upper division students to the fundamentals of medical instrumentation. Specifically, it will teach the physiological/physicochemical, biomechanical, computational and electronic principles governing the operation of select medical instrumentation. Focusing on classical and modern instrumentation used in specific clinical departments, such as cardiology, pulmonary medicine and critical care, radiology, and anesthesiology, the course will also introduce the students to the operation, safety aspects, and calibration of electronic, optical and acoustical instruments, as well as those involving ionizing radiation.

Department Restrictions: Must be enrolled in one of the following Departments: Engineering:Bio Engineering.
Field of Study Restrictions: Must be enrolled in one of the following Majors: Bioengineering.

Repeatability: This course may not be repeated for additional credits.

Pre-requisites: Minimum grade of C- in (PHYS 1062 or PHYS 2022) and (MATH 1042, MATH 1942, or 'Y' in MATW)

BIOE 3301. Biomedical Signals and Systems. 3 Credit Hours.

This course will expose students to digital signal processing with emphasis on problems in biomedical research and clinical medicine. It covers principles and algorithms for processing signals and systems in both continuous and discrete time domains with examples from biomedical signal processing and control. Theory and practice of Continuous-time linear systems: convolution, steady-state responses, Fourier and Laplace transforms, transfer functions, poles and zeros, stability, sampling, feedback. Discrete-time linear systems: Z transform, filters, Fourier transform, signal processing. This class will make extensive use of Matlab projects.

Department Restrictions: Must be enrolled in one of the following Departments: Engineering:Bio Engineering.
Field of Study Restrictions: Must be enrolled in one of the following Majors: Bioengineering.

Repeatability: This course may not be repeated for additional credits.

Pre-requisites: Minimum grade of C- in (MATH 2101, ENGR 2011, or MEE 2011)

BIOE 3302. Drug Delivery. 3 Credit Hours.

This course will cover the engineering principles utilized in the design of drug delivery systems. Topics will include: drug delivery mechanisms (oral, parenteral, passive, targeted, etc.); therapeutic modalities and mechanisms of action; engineering principles of controlled release and quantitative understanding of drug transport (diffusion, convection); effects of electrostatics, macromolecular conformation, and molecular dynamics on interfacial interactions; thermodynamic principles of self-assembly; chemical and physical characteristics of delivery molecules and assemblies (polymer based, lipid based); significance of biodistributions and pharmacokinetic models; toxicity issues and immune responses.

Department Restrictions: Must be enrolled in one of the following Departments: Engineering:Bio Engineering.
Field of Study Restrictions: Must be enrolled in one of the following Majors: Bioengineering.

Repeatability: This course may not be repeated for additional credits.

Pre-requisites: Minimum grade of C- in (MATH 2041 (may be taken concurrently), MATH 2941 (may be taken concurrently), MATH 3041 (may be taken concurrently), or MATH 3941 (may be taken concurrently))

BIOE 3303. Biotransport Phenomena. 3 Credit Hours.

This course will provide students with a quantitative understanding of mass (convection and diffusion) and momentum transport (viscous flow) in living systems, both at macroscopic and microscopic scales. We'll introduce differential equations to model and quantify aspects of bioengineering systems will be covered. Example systems will include the analysis of fluid flow phenomena in the cardiovascular, respiratory and other human organ systems, membrane transport, drug delivery and molecular transport.

Department Restrictions: Must be enrolled in one of the following Departments: Engineering:Bio Engineering.
Field of Study Restrictions: Must be enrolled in one of the following Majors: Bioengineering.

Repeatability: This course may not be repeated for additional credits.

Pre-requisites: Minimum grade of C- in ENGR 3571 and (CHEM 1031, CHEM 1035, or CHEM 1951)

BIOE 3312. Mechanics for Bioengineering II. 4 Credit Hours.

This course will provide students with an understanding of the application of mechanics of solids and dynamics to engineering problem analyses. Topics will introduce basic concepts of dynamics and mechanics with application to physiologic loading and motion in the body.

Department Restrictions: Must be enrolled in one of the following Departments: Engineering:Bio Engineering.
Field of Study Restrictions: Must be enrolled in one of the following Majors: Bioengineering.

Repeatability: This course may not be repeated for additional credits.

Pre-requisites: Minimum grade of C- in BIOE 2312.

BIOE 3331. Principles of Macromolecular Science. 3 Credit Hours.

In this course students will gain an understanding of the fundamentals of polymer physical chemistry. We will cover polymer structure and conformation, bulk and solution thermodynamics and phase behavior, polymer networks, and viscoelasticity. We will also apply engineering principles to the analysis of biomacromolecules, such as proteins, polysaccharides and oligonucleotides. Upon the completion of the course, students should be able to understand the influence of monomer structure, temperature, solution conditions, degree of polymerization and 3D conformation on the function of biopolymers.

Department Restrictions: Must be enrolled in one of the following Departments: Engineering:Bio Engineering.
Field of Study Restrictions: Must be enrolled in one of the following Majors: Bioengineering.

Repeatability: This course may not be repeated for additional credits.

Pre-requisites: Minimum grade of C- in (CHEM 1032 or CHEM 1952)

BIOE 3401. Biodesign - Testing and Validation. 3 Credit Hours.

This course aims to reinforce the Design Thinking concepts introduced earlier in the curriculum. Students will apply Design Thinking concepts to team projects. We will introduce topics in project management, machine shop use, computer modeling, ethical conduct of research and translational/entrepreneurial considerations, in addition to building upon the tools acquired and used in the Bioengineering Design I. The first part of the semester will be used for problem statement development and creations of several alternative design solutions. The second part of the semester will then be devoted to prototyping, testing and optimizing the proposed solutions, with oral presentations and written reports of their progress in the project throughout the semester.

Repeatability: This course may not be repeated for additional credits.

Pre-requisites: Minimum grade of C- in (MATH 1042 or 'Y' in MATW), (PHYS 1062 or PHYS 2022), and ENGR 1101.

BIOE 3511. Interactions of Biomaterials with Living Tissues. 3 Credit Hours.

This course will cover topics that illustrate how biomaterials interact with living tissues, focusing on cell culture, immunology, cell-biomaterial interfaces, and cell signaling. The students will learn the fundamentals maintaining living cells in culture and how these cells react to the presence of biomaterials using lecture and laboratory format.

Department Restrictions: Must be enrolled in one of the following Departments: Engineering:Bio Engineering.
Field of Study Restrictions: Must be enrolled in one of the following Majors: Bioengineering.

Repeatability: This course may not be repeated for additional credits.

Pre-requisites: Minimum grade of C- in BIOE 2101 and (CHEM 1031, CHEM 1035, or CHEM 1951)

BIOE 3719. Introduction to Bioengineering. 3 Credit Hours.

Course topics include biomaterials and implant materials, research proposal preparation, tyrosine-derived synthetic polymer devices for tissue engineering spine biomechanics, cellular material biomechanics, orthopedic biomechanics, hydroxyapatite/polymer composites, applications of injury biomechanics, biomechanics of the lower extremities, principles of polymers used in dental and biomaterials, interfaces in biomaterials. Students will be required to prepare a proposal for a design-oriented term project (i.e. rationale, concept and design, but no actual construction).

Class Restrictions: Must be enrolled in one of the following Classes: Junior 60 to 89 Credits, Senior 90 to 119 Credits, Senior/Fifth Year 120+ Credits.
College Restrictions: Must be enrolled in one of the following Colleges: Engineering.

Repeatability: This course may not be repeated for additional credits.

BIOE 3725. Cell Biology for Engineers. 3 Credit Hours.

Cell Biology for Engineers is a basic course that introduces biological concepts in modern cellular and molecular biology to engineering students. Topics will include the chemical composition of cells, bioenergetics and metabolism, structure and function of the plasma membrane, transport across membranes, the cytoplasmic membrane system, the extracellular matrix, interactions between cells and their environment, the cytoskeleton and cell motility, sensory systems, and cell signaling. In addition, an introduction to basic anatomy and physiology of vertebrates will include the skeletal system, muscle system, cardiovascular system, and nervous system.

College Restrictions: Must be enrolled in one of the following Colleges: Engineering.

Repeatability: This course may not be repeated for additional credits.

Pre-requisites: Minimum grade of C- in (CHEM 1031, CHEM 1035, or CHEM 1951)

BIOE 4101. BioE Lab #3 - Biomechanics. 3 Credit Hours.

In this course students will apply principles of engineering mechanics in the design and utilization of biomechanical instrumentation. Principles of transduction, mechanics, sampling theory, strain, temperature, and flow measurement as applied to biomechanical systems will be covered. A background in data acquisition, electrical safety, operational amplifier and bridge circuits, and measurements is provided. Students will investigate the biomechanics of the musculoskeletal and cardiovascular systems in normal and pathological states.

Department Restrictions: Must be enrolled in one of the following Departments: Engineering:Bio Engineering.
Field of Study Restrictions: Must be enrolled in one of the following Majors: Bioengineering.

Repeatability: This course may not be repeated for additional credits.

Pre-requisites: Minimum grade of C- in BIOE 3101.

BIOE 4182. Independent Study in Bioengineering. 1 to 5 Credit Hour.

Independent study course in bioengineering. Credits are arranged with instructor.

Repeatability: This course may be repeated for additional credit.

BIOE 4278. Cardiac Devices. 3 Credit Hours.

Intended for electrical engineering, biology, and bioengineering students. No course prerequisites. This course will cover cardiac anatomy and physiology, the heart's electrical system in health and disease, cardiac ECG rhythm interpretation, design and function of ECG monitoring devices, pacemakers and external and implanted defibrillators, and arrhythmia detection algorithms. The course will include observation of pacemaker implants, and troubleshooting in a pacemaker follow-up clinic. The course will prepare students to take the Heart Rhythm Society Allied Professional Pacemaker Certification examination. It is intended to put students in a competitive advantage for getting jobs in the expanding pacemaker and other medical electronics device industries.

Repeatability: This course may not be repeated for additional credits.

BIOE 4301. Bioengineering Seminar. 1 Credit Hour.

This seminar is intended for bioengineering students who are interested in acquiring hands-on presentation skills and, in addition, keeping up-to-date with the bioengineering research fields. The aim of the class is to allow upper division students to present a summarized view of a specific bioengineering or biomedical engineering topic. Specific topics that will be suggested to be covered (by the students) are biomaterials, tissue/regenerative engineering, bioimaging, biosensing, bionanotechnology (or nanobiotechnology), neuroengineering, bioinformatics (computational), biomechanics, (but are not limited to them). Guest lecturers from academia and industry will be invited to talk on several occasions.

Department Restrictions: Must be enrolled in one of the following Departments: Engineering:Bio Engineering.
Field of Study Restrictions: Must be enrolled in one of the following Majors: Bioengineering.
Class Restrictions: Must be enrolled in one of the following Classes: Junior 60 to 89 Credits, Senior 90 to 119 Credits, Senior/Fifth Year 120+ Credits.

Repeatability: This course may not be repeated for additional credits.

Pre-requisites: Minimum grade of C- in BIOE 2001.

BIOE 4311. The Entrepreneurial Bioengineer. 3 Credit Hours.

Recognizing the increasingly entrepreneurial landscape of Bioengineering, this course will introduce the students to the fundamentals of entrepreneurship and is designed to provide students with a working knowledge of the modern entrepreneurial and business planning and the regulatory process with the special focus on translational development of bioengineering products from the bench to the bedside.

Department Restrictions: Must be enrolled in one of the following Departments: Engineering:Bio Engineering.
Field of Study Restrictions: Must be enrolled in one of the following Majors: Bioengineering.
Class Restrictions: Must be enrolled in one of the following Classes: Junior 60 to 89 Credits, Senior 90 to 119 Credits, Senior/Fifth Year 120+ Credits.

Repeatability: This course may not be repeated for additional credits.

Pre-requisites: Minimum grade of C- in BIOE 2001 (may be taken concurrently)

BIOE 4333. Capstone Elective: Applied Biospectroscopy. 3 Credit Hours.

This course introduces the basics of light propagation in tissue and other turbid media, vibrational spectroscopy, absorption and fluorescence, and emerging spectroscopic applications. Emphasis is on applications for assessment of biomolecules, engineered tissues and clinically-relevant analyses including musculoskeletal disease and cancer diagnosis. Multivariate analyses for complex spectral data sets will also be introduced.

Level Registration Restrictions: Must be enrolled in one of the following Levels: Undergraduate.

Repeatability: This course may not be repeated for additional credits.

Pre-requisites: Minimum grade of C- in BIOE 2101, BIOE 3001, and BIOE 3101.

BIOE 4411. Capstone Elective: Biomaterials. 3 Credit Hours.

This course will focus on materials and design parameters used to develop human implant devices, bulk and surface characterization methods for biomaterials, biocompatibility, failure mechanisms of current biomaterials, and regulatory requirements for design and testing of human implant devices. Special attention will be given to biomaterials used in tissue regeneration, orthopedics, and controlled drug delivery.

Department Restrictions: Must be enrolled in one of the following Departments: Engineering:Bio Engineering.
Field of Study Restrictions: Must be enrolled in one of the following Majors: Bioengineering.

Repeatability: This course may not be repeated for additional credits.

Pre-requisites: Minimum grade of C- in BIOE 2101 and CHEM 2201.

BIOE 4421. Capstone Elective: Bionanotechnology. 3 Credit Hours.

This course is intended for upper division students interested in acquiring knowledge involving nanometer-sized objects frequently utilized within the biomedical sciences and engineering areas. The aim of the class is to introduce fundamental concepts critical in the design, preparation, analysis, and usage of bionanotechnology (or nanobiotechnology) and its multiple bottom-up and top-down approaches. Multiple nanomaterials categories, such as nanoparticles, nanotubes, biomacromolecules, synthetic polymers, and self-assembled structures, will be covered in detail along with their applications.

Repeatability: This course may not be repeated for additional credits.

Pre-requisites: Minimum grade of C- in CHEM 2201 and BIOE 1301.

BIOE 4431. Capstone Elective: Neuroengineering. 3 Credit Hours.

This course will teach students how signals are generated and propagated in neurons and neuronal circuits, and how this knowledge can be utilized to engineer devices to assist people with neurologic disease or injury. The functions of neurons as discrete elements and as parts of neuronal assemblies will be examined; generator and action potentials; conduction in nerve fibers and across synaptic junctions; analysis of sensory and neuromuscular systems; EEG and EKG waveforms. At the completion of the course, students will have gained a fundamental understanding of neural interface/prosthetics design parameters from basic neural physiology to models of neural mechanisms. We will also review advanced neural interfaces currently being developed and or produced commercially by the field.

Department Restrictions: Must be enrolled in one of the following Departments: Engineering:Bio Engineering.
Field of Study Restrictions: Must be enrolled in one of the following Majors: Bioengineering.

Repeatability: This course may not be repeated for additional credits.

Pre-requisites: Minimum grade of C- in BIOE 2101 and (MATH 2041 (may be taken concurrently), MATH 2941 (may be taken concurrently), MATH 3041 (may be taken concurrently), or MATH 3941 (may be taken concurrently))

BIOE 4441. Capstone Elective: Biomechanics. 3 Credit Hours.

This course will provide an integrative and multi-scale understanding of biomechanics that spans from tissues, to organs, to the dynamics of an intact, running body. Foundational topics will include muscle mechanics, skeletal mechanics, gait and whole body dynamics. The course will then move on to cover selected topics at the forefront of applied biomechanics including clinical biomechanics and the design and optimization of prosthetic limbs. Finally, frontiers in neural-interfacing for prostheses and rehabilitation, including optogenetics and other emerging areas affecting biomechanics, including robotics and robotic exoskeletons, will be covered.

Department Restrictions: Must be enrolled in one of the following Departments: Engineering:Bio Engineering.
Field of Study Restrictions: Must be enrolled in one of the following Majors: Bioengineering.
College Restrictions: Must be enrolled in one of the following Colleges: Engineering.

Repeatability: This course may not be repeated for additional credits.

Pre-requisites: Minimum grade of C- in (BIOE 2101 or BIOE 3725) and (BIOE 3312 or (ENGR 2332 and ENGR 2333))

BIOE 4451. Capstone Elective: Biomedical Imaging. 3 Credit Hours.

In this course students learn how light, X-rays, radiopharmaceuticals, ultrasound, magnetic fields, and other energy probes are generated and how they interact with tissues and detectors to produce useful image contrast. Practical issues such as beam generation, dose limitations, patient motion, spatial resolution and dynamic range limitations, and cost-effectiveness will be addressed. Emphasis will be placed on diagnostic radiological imaging physics, including the planar X-ray, digital subtraction angiography mammography, computed tomography, nuclear medicine, ultrasound, and magnetic resonance imaging modalities.

Department Restrictions: Must be enrolled in one of the following Departments: Engineering:Bio Engineering.
Field of Study Restrictions: Must be enrolled in one of the following Majors: Bioengineering.

Repeatability: This course may not be repeated for additional credits.

Pre-requisites: Minimum grade of C- in PHYS 1062, (CHEM 1031, CHEM 1035, or CHEM 1951), (BIOL 1111, BIOL 1012, BIOL 2112, BIOL 1911, BIOL 2912, or 'Y' in BIOW), and (MATH 2041, MATH 2941, MATH 3041, or MATH 3941)

BIOE 4461. Capstone Elective: Principles of Tissue Engineering. 3 Credit Hours.

This course will introduce fundamental concepts of tissue engineering and regenerative medicine, focusing on biomaterials used for scaffolds, mechanisms of cell-biomaterial interactions, biocompatibility and foreign body response, cellular engineering, and tissue biomechanics. Principles of cell/developmental and stem cell biology will be introduced, which will enable the students to apply a multidisciplinary approach to engineering select tissues and organs, such as the musculoskeletal system, cardiovascular tissues, the nervous system, and to design artificial organs. These topics will also be discussed in the context of scale-up, manufacturing, ethical and regulatory concerns. Note: Prior to fall 2017, the course title was "Capstone Elective: Principles of Tissue and Regenerative Engineering."

Department Restrictions: Must be enrolled in one of the following Departments: Engineering:Bio Engineering.
Field of Study Restrictions: Must be enrolled in one of the following Majors: Bioengineering.

Repeatability: This course may not be repeated for additional credits.

Pre-requisites: Minimum grade of C- in BIOE 2101 and CHEM 2202.

BIOE 4471. Mechanobiology. 3 Credit Hours.

Mechanobiology is an emerging interdisciplinary field that focuses on the role of mechanical cues in governing cellular behavior. This course will address the means by which a cell utilizes its adhesions to neighboring cells and to the surrounding extracellular matrix to sense external forces and furthermore, how these forces are transduced within the cell to alter cellular behavior and regulate tissue architecture. This course will also discuss how the extracellular matrix influences cellular behavior during development, health, and disease. Furthermore, this course will also discuss the various tools and techniques developed that pushed the field of mechanobiology forward.

Repeatability: This course may not be repeated for additional credits.

Pre-requisites: Minimum grade of C- in (BIOL 1012, BIOL 2112, or BIOL 2912), BIOE 3001, and (BIOE 2312 or BIOE 4101)

BIOE 4500. Special Topics in Bioengineering. 3 Credit Hours.

An emerging or advanced area of bioengineering research will be covered. Topics vary by semester.

Field of Study Restrictions: Must be enrolled in one of the following Fields of study: Bioengineering.

Repeatability: This course may be repeated for additional credit.

BIOE 4501. Capstone Elective: Regenerative Engineering. 3 Credit Hours.

This course is a continuation of fundamental concepts introduced in Principles of Tissue and Regenerative Engineering focusing on developmental biology used in tissue engineering and regenerative medicine. Principles of cell development/biology, cell-cell interactions, signal transduction, and stem cell biology will be discussed with applications to regenerative medicine. These topics will also be discussed in the context of scale-up, manufacturing, ethical and regulatory concerns.

Department Restrictions: Must be enrolled in one of the following Departments: Engineering:Bio Engineering.
Field of Study Restrictions: Must be enrolled in one of the following Majors: Bioengineering.
Class Restrictions: Must be enrolled in one of the following Classes: Senior 90 to 119 Credits, Senior/Fifth Year 120+ Credits.

Repeatability: This course may not be repeated for additional credits.

Pre-requisites: Minimum grade of C- in BIOE 2101 and (CHEM 2202 or CHEM 2922)

BIOE 4555. Capstone Elective - Biophotonics: Seeing is Believing. 3 Credit Hours.

Only a small portion of the world around us is visible to the human eye. So, is there a way to visualize chaos, force, fractals, viral infection or cancer metastasis? Once we see biology happen, is the result a pretty image or a valuable measurement? Can the light be used to modify biological processes? In this course students will learn how photons are used to visualize and manipulate biomaterials at multiple scales. The first part of the course will provide a review of electromagnetism, light and optics. We will cover typical hardware used for imaging in biology, such as light sources, objectives and detectors used to generate images. Next, chemistry of imaging probes will be covered, including photochemistry and interaction of light and matter. The rest of the course will give a comprehensive overview of methodologies for multiscale imaging in life sciences, ranging from electron to atomic-molecular-cell-multicellular tissue-whole body scales, in vitro and in vivo. This will include among others Spectroscopy, Microscopy (Electron, Atomic, Fluorescent), Flow Cytometry, Optical Traps, Bioluminescence, X-Ray, MRI. Final classes will include special demonstrations in the imaging labs in the Temple Main Campus.

Field of Study Restrictions: Must be enrolled in one of the following Fields of study: Bioengineering.

Repeatability: This course may not be repeated for additional credits.

Pre-requisites: Minimum grade of C- in (PHYS 1062 or PHYS 2022), CHEM 2202, and (BIOL 2112, BIOE 3102 (may be taken concurrently), or 'Y' in BIOW)

BIOE 4741. Biomaterials for Engineers. 3 Credit Hours.

This course introduces engineering students to materials as they interact with biological systems, primarily in medicine. Topics will include a review of properties of materials, the classes of materials, tissues that come into contact with materials, the degradation of materials in the biological environment, the application of materials for specific uses, tissue engineering, and biomaterials standards and regulations.

Field of Study Restrictions: May not be enrolled in one of the following Majors: Bioengineering.
Class Restrictions: Must be enrolled in one of the following Classes: Junior 60 to 89 Credits, Senior 90 to 119 Credits, Senior/Fifth Year 120+ Credits.

Repeatability: This course may not be repeated for additional credits.

Pre-requisites: Minimum grade of C- in (CHEM 1031, CHEM 1035, or CHEM 1951)