Bioengineering

Peter Lelkes, Ph.D., Chair
Room 811, Engineering Building
215-204-3307
pilelkes@temple.edu

Ruth Ochia, Ph.D., Undergraduate Coordinator
Room 813, Engineering Building
215-204-3038
ruth.ochia@temple.edu

http://engineering.temple.edu/department/bioengineering

Goals, Objectives & Design Integration

The Bioengineering program will be able to integrate engineering science, rigorous mathematical tools and a quantitative approach to the life sciences and apply this spectrum of knowledge in an interdisciplinary fashion to provide solutions to basic and applied biological and medical problems.

This goal will be accomplished by offering to the students an integrated set of courses aimed at providing a thorough introduction to the complex and interdisciplinary field of Bioengineering:

  • Teach engineering science, analysis, and design in the context of quantitative approaches to solving life science and medicine-related problems.
  • Integrate interdisciplinary aspects of biology, physiology, and engineering within courses and design projects.
  • Emphasize the interdisciplinary nature of Bioengineering, in terms of problem solving, design, within the framework of interdisciplinary teams focusing on the dialogue between "biology-inspired engineering" and "biology as a specific arm of applied engineering principles."
  • Immerse students in key life science and medical principles, while focusing on understanding cell/molecular-level events through quantitative analysis and modeling.
  • Provide an exceptional learning environment with significant instruction by Bioengineering faculty and researchers in collaboration with experts from other fields, especially the Health Science Campus.

In this curriculum, incoming freshmen will first and foremost be trained as solid Temple engineers, focusing on applying engineering science, design, and analysis to real life problems specifically in the areas of biology and medicine. This firm engineering foundation will be further enhanced with newly developed Bioengineering courses in specific pathways, such as:

  • Biomaterials: A focus on the design, development, and uses of biomaterials in biology and medicine. It also explores the host-biomaterial interface and interactions.
  • Bioimaging: A focus on design, development, and uses of imaging modalities and techniques in biology.
  • Bioinstrumentation: A focus on the design, development, and use of instruments used to record, process, and/or control biological functions.
  • Biomechanics: A focus on the interaction between forces and motions in tissues, organisms, and biomedical materials.
  • Tissue Engineering: A focus on building functional tissues using cells and scaffolds and repairing diseased tissues and organs at the cellular and molecular level.
  • Neuroengineering: A focus on using engineering to understand and interact with neural tissues.
  • Pre-med: A broad-based Bioengineering curriculum which fulfills current pre-med course requirements.

Hands-on engineering experience will be gained through intense laboratory coursework and by solving real-life biomedical problems. 

Summary of Requirements

University Requirements

All new students are required to complete the university's General Education (GenEd) curriculum.

All Temple students must take a minimum of two writing-intensive courses for a total of at least six credits. The writing-intensive course credits are counted as part of the major; they are not General Education (GenEd) or elective credits. The writing-intensive courses must be completed at Temple University and students may not transfer in credits to satisfy this requirement. The specific writing-intensive courses required for this major are: 

ENGR 2196Technical Communication3
or ENGR 2996 Honors Technical Communication by Design
ENGR 4196Senior Design Project I1
ENGR 4296Senior Design Project II3
or ENGR 4996 Honors Senior Design Project II

Department and Major Requirements

Foundation Science & Math Courses in Engineering
MATH 1041Calculus I4
or MATH 1941 Honors Calculus I
MATH 1042Calculus II4
or MATH 1942 Honors Calculus II
MATH 2043Calculus III4
or MATH 2943 Honors Calculus III
MATH 3041Differential Equations I3
Select one of the following:4
Introduction to Biology I
General Biology II
Introduction to Biology II
Honors Introduction to Biology I
Honors Introduction to Biology II
Select one of the following:3
General Chemistry I
Chemistry for Engineers
Honors General Chemical Science I
CHEM 1033General Chemistry Laboratory I1
or CHEM 1953 Honors Chemical Science Laboratory I
Select one of the following:4
Elementary Classical Physics I
Honors Elementary Classical Physics I
General Physics I
Honors General Physics I
Select one of the following:4
Elementary Classical Physics II
Honors Elementary Classical Physics II
General Physics II
Honors General Physics II
Required General Education Courses
Select one of the following:4
Analytical Reading and Writing
Analytical Reading and Writing: ESL
Honors Literature/Reading/Writing
IH 0851Mosaic: Humanities Seminar I3
or IH 0951 Honors Mosaic: Humanities Seminar I
IH 0852Mosaic: Humanities Seminar II3
or IH 0952 Honors Mosaic: Humanities Seminar II
GenEd 08xx or 09xx (Human Behavior)3
GenEd 08xx or 09xx (Race and Diversity)3
GenEd 08xx or 09xx (Global/World Society)3
GenEd 08xx or 09xx (U.S. Society)3
GenEd 08xx or 09xx (Arts)3
Required Engineering Courses
ENGR 1101Introduction to Engineering & Engineering Technology3
or ENGR 1901 Honors Introduction to Engineering
ENGR 3571Classical and Statistical Thermodynamics3
BIOE 2001Frontiers in Bioengineering2
BIOE 2101Engineering Principles of Physiological Systems3
BIOE 3001Research Design and Methods in Bioengineering2
BIOE 3101BioE Lab #1 - Bioelectrical Engineering3
BIOE 3102BioE Lab #2 - Biomaterials3
BIOE 4101BioE Lab #3 - Biomechanics3
BIOE 3201Biomedical Instrumentation2
BIOE Elective #13
BIOE Elective #23
BIOE Elective #33
Capstone Elective3
ENGR 2196Technical Communication (WI)3
or ENGR 2996 Honors Technical Communication by Design
ENGR 3033Entrepreneurial Engineering3
or BIOE 4311 The Entrepreneurial Bioengineer
ENGR 4169Engineering Seminar1
ENGR 4196Senior Design Project I (WI)1
ENGR 4296Senior Design Project II (WI)3
or ENGR 4996 Honors Senior Design Project II
Technical Electives
Technical Elective #13
Technical Elective #24
Technical Elective #34
Technical Elective #44
Free Electives
Free Elective #13
Free Elective #23
Total Credit Hours124

Suggested Academic Plan

Please note that this is a suggested academic plan. Depending on your pathway, your academic plan may look different.

Bachelor of Science in Bioengineering

Requirements for New Students starting in the 2016-2017 Academic Year

Year 1
FallCredit Hours
MATH 1041 or 1941Calculus I4
Select one of the following:3
General Chemistry I 
Chemistry for Engineers 
Honors General Chemical Science I 
CHEM 1033 or 1953General Chemistry Laboratory I1
ENG 0802, 0812, or 0902Analytical Reading and Writing [GW]4
ENGR 1101 or 1901Introduction to Engineering Engineering Technology3
 Term Credit Hours15
Spring
MATH 1042 or 1942Calculus II4
Technical Elective #13
Select one of the following:4
Elementary Classical Physics I 
Honors Elementary Classical Physics I 
General Physics I 
Honors General Physics I 
IH 0851 or 0951Mosaic: Humanities Seminar I [GY]3
BIOE 2001Frontiers in Bioengineering2
 Term Credit Hours16
Year 2
Fall
MATH 2043 or 2943Calculus III4
Select one of the following:4
Elementary Classical Physics II 
Honors Elementary Classical Physics II 
General Physics II 
Honors General Physics II 
Technical Elective #24
ENGR 2196 or 2996Technical Communication [WI]3
 Term Credit Hours15
Spring
MATH 3041Differential Equations I3
ENGR 3571Classical and Statistical Thermodynamics3
BIOE 2101Engineering Principles of Physiological Systems3
IH 0852 or 0952Mosaic: Humanities Seminar II [GZ]3
Select one of the following:4
Introduction to Biology I 
General Biology II 
Introduction to Biology II 
Honors Introduction to Biology I 
Honors Introduction to Biology II 
 Term Credit Hours16
Year 3
Fall
BIOE 3001Research Design and Methods in Bioengineering2
BIOE 3101BioE Lab #1 - Bioelectrical Engineering3
GenEd Breadth Course3
BIOE 3201Biomedical Instrumentation2
BIOE Elective #13
Free Elective #13
 Term Credit Hours16
Spring
BIOE 3102BioE Lab #2 - Biomaterials3
BIOE Elective #24-3
GenEd Breadth Course3
ENGR 4169Engineering Seminar1
Select one of the following:2-3
Entrepreneurial Engineering 
The Entrepreneurial Bioengineer 
Technical Elective #34
 Term Credit Hours17
Year 4
Fall
BIOE 4101BioE Lab #3 - Biomechanics3
ENGR 4196Senior Design Project I [WI]1
Capstone Elective3
GenEd Breadth Course3
GenEd Breadth Course3
 Term Credit Hours13
Spring
ENGR 4296 or 4996Senior Design Project II [WI]3
BIOE Elective #33
GenEd Breadth Course3
Free Elective #23
Technical Elective #44
 Term Credit Hours16
 Total Credit Hours: 124
Technical Electives
BIOL 1111Introduction to Biology I4
or BIOL 1911 Honors Introduction to Biology I
BIOL 2112Introduction to Biology II4
or BIOL 2912 Honors Introduction to Biology II
BIOL 3096Cell Structure and Function4
BIOL 3352Systems Neuroscience3
BIOL 3354Neural Basis of Animal Behavior3
CIS 1053Programming in Matlab4
CIS 1057Computer Programming in C4
Select one of the following:4
General Chemistry II
and General Chemistry Laboratory II
Honors General Chemical Science II
and Honors Chemical Science Laboratory II
Select one of the following:4
Organic Chemistry I
and Organic Chemistry Laboratory I
Organic Chemistry for Honors I
and Organic Honors Laboratory I
Select one of the following:4
Organic Chemistry II
and Organic Chemistry Laboratory II
Organic Chemistry for Honors II
and Organic Honors Laboratory II
CHEM 4401Biochemistry I3
ECE 2332
ECE 2333
Principles of Electric Circuits
and Principles of Electric Circuits Lab
5
ECE 3412
ECE 3413
Classical Control Systems
and Classical Control Laboratory
4
ECE 3512Signals: Continuous and Discrete4
or ECE 3912 Honors Signals: Continuous and Discrete
ENGR 1117Engineering Graphics2
ENGR 2011Engineering Analysis & Applications3
or MATH 2101 Linear Algebra
or MEE 2011 Linear Systems
ENGR 3117Computer-Aided Design (CAD)3
ENGR 3201Material Science for Engineers3
ENGR 3553Mechanics of Fluids3
or ENGR 3953 Honors Mechanics of Fluids
Bioengineering Electives
BIOE 2301Quantitative Pathophysiology3
BIOE 2302Cellular and Molecular Biology for Bioengineers3
BIOE 2312Mechanics for Bioengineering I4
BIOE 3301Biomedical Signals and Systems3
BIOE 3302Drug Delivery3
BIOE 3303Biotransport Phenomena3
BIOE 3312Mechanics for Bioengineering II4
BIOE 3331Principles of Macromolecular Science3
BIOE 3511Interactions of Biomaterials with Living Tissues3
BIOE 3719Introduction to Bioengineering3
BIOE 3725Cell Biology for Engineers3
BIOE 4278Cardiac Devices3
BIOE 4301Bioengineering Seminar1
BIOE 4501Regenerative Engineering3
BIOE 4741Biomaterials for Engineers3
Capstone Electives
BIOE 4333Applied Biospectroscopy3
BIOE 4411Capstone Elective: Biomaterials3
BIOE 4431Capstone Elective: Neuroengineering3
BIOE 4421Capstone Elective: Bionanotechnology3
BIOE 4441Capstone Elective: Biomechanics3
BIOE 4451Capstone Elective: Biomedical Imaging3
BIOE 4461Capstone Elective: Principles of Tissue and Regenerative Engineering3
BIOE 4555Capstone Elective - Biophotonics: Seeing is Believing3

Courses

BIOE 0856. Ethical Issues in Biomedical Science, Engineering and Technology. 3 Credit Hours.

At some point in our lives, each of us will be confronted with difficult biomedical and biotechnological questions that present an ethical dilemma. This course is designed to enable you to critically address important issues in ethics that arise from advances in these fields. We will consider potential advantages of using modern technologies to improve human health, in contrast to the risks associated with their application. Some of the questions we will pose include: Is it acceptable to use technology to restore our bodies to a pre-injury state? If so, what about using technology to enhance our bodies to improve our performance? What are the implications of the use of reproductive technology that results in one child having three biological parents? Can a physician text a picture of an X-ray to another colleague? These questions, and many others, will be explored in detail through class and small group discussions, coupled with analysis of current news events and scientific publications. Evidence-based approaches will be used to investigate issues related to a variety of subjects including use/overuse of imaging modalities, organ transplant, regenerative tissue engineering and medicine, human enhancements, genetic engineering, personalized medicine, reproductive control (e.g. IVF, surrogate pregnancy), cloning, stem cell use, medical privacy in the era of the electronic medical record, texting, and Instagram, and animal testing for cosmetics, drugs, or medical devices.

Course Attributes: GS

Repeatability: This course may not be repeated for additional credits.

BIOE 2001. Frontiers in Bioengineering. 2 Credit Hours.

This survey course will provide a first introduction to the wide scope of biomedical engineering, with emphasis on the application of engineering principles to solving problems in biology and medicine. Specific topics will include biomechanics; bioimaging; bioinstrumentation and biomedical devices; artificial organs; computational biology and bioinformatics; biomaterials and drug delivery; cellular, tissue and regenerative engineering; and nanobiotechnology. At the end of this introductory course the students will be familiar with some of the major molecular, cellular, physiological and engineering principles that allow for problem solving in the vast area of biomedical engineering. Thus the students will be prepared to study in depth some of the specialized topics of bioengineering.

Repeatability: This course may not be repeated for additional credits.

BIOE 2101. Engineering Principles of Physiological Systems. 3 Credit Hours.

This course will introduce biomedical engineering students to quantitative modeling of physiological systems. It will cover fundamental topics in physiology ranging from cell membrane models and chemical messengers to neuronal signaling and control of body movement. In addition, specific physiological systems are discussed in detail, including the cardiovascular, pulmonary, and visual systems. Furthermore, pharmacokinetic models provide quantitative assessment of the dynamics of drug distribution and compartmental interactions. Hands-on laboratories combining actual experiments with computer simulations will reinforce the contents of classroom teaching.

Department restrictions: Must be enrolled in one of the following Departments: Engineering:Bio Engineering
Field of Study Restrictions: Must be enrolled in one of the following Fields of study: Bioengineering

Repeatability: This course may not be repeated for additional credits

Pre-requisites:
BIOL 1111|Minimum Grade of C-|May be taken concurrently
OR BIOL 2112|Minimum Grade of C-|May be taken concurrently
OR BIOL 1012|Minimum Grade of C-|May be taken concurrently
OR BIOL 1911|Minimum Grade of C-|May be taken concurrently
OR BIOL 2912|Minimum Grade of C-|May be taken concurrently.

BIOE 2301. Quantitative Pathophysiology. 3 Credit Hours.

This course will introduce students to fundamental principles of human pathophysiology. Students will gain a systems level understanding of disease processes necessary for the rational design of novel therapeutic and diagnostic technologies. The course will integrate basic biological science and fundamental engineering principles in the evaluation of clinical disease manifestations. Topics that will be covered include: fundamental concepts of cellular homeostasis; cellular responses (adaptation, injury, cell death) induced by stress, injurious stimuli, and disease, and systemic models of major diseases within the US (cardiac, neoplastic, cerebrovascular, traumatic, neurodegenerative, diabetic, and pulmonary).

Department restrictions: Must be enrolled in one of the following Departments: Engineering:Bio Engineering
Field of Study Restrictions: Must be enrolled in one of the following Majors: Bioengineering

Repeatability: This course may not be repeated for additional credits

Pre-requisites:
BIOL 1111|Minimum Grade of C-|May not be taken concurrently
OR BIOL 2112|Minimum Grade of C-|May not be taken concurrently
OR BIOL 1012|Minimum Grade of C-|May not be taken concurrently
OR BIOL 1911|Minimum Grade of C-|May not be taken concurrently
OR BIOL 2912|Minimum Grade of C-|May not be taken concurrently.

BIOE 2302. Cellular and Molecular Biology for Bioengineers. 3 Credit Hours.

This course will enhance the basic knowledge of the students in quantitative cell and molecular biology from the vantage point of a bioengineer, focusing on molecular mechanisms and cellular functions, specifically in cell-cell and cell-matrix communications. Textbook learning will be supplemented with results from recent research and technological innovations in biology. After completing this course, bioengineering students will be able to apply their aptitude in the quantitative, physical and engineering sciences to modern biology. Students will also learn the principles how to establish and test biological models.

Department restrictions: Must be enrolled in one of the following Departments: Engineering:Bio Engineering
Field of Study Restrictions: Must be enrolled in one of the following Majors: Bioengineering

Repeatability: This course may not be repeated for additional credits

Pre-requisites:
BIOE 2101|Minimum Grade of C-|May not be taken concurrently.

BIOE 2312. Mechanics for Bioengineering I. 4 Credit Hours.

This course will provide students with an understanding of the application of statics and strength of materials to biomechanical problem analyses. Topics will introduce basic concepts of mechanics and kinetic analyses with application to physiologic loading and motion in the body.

Department restrictions: Must be enrolled in one of the following Departments: Engineering:Bio Engineering
Field of Study Restrictions: Must be enrolled in one of the following Majors: Bioengineering

Repeatability: This course may not be repeated for additional credits

Pre-requisites:
(PHYS 1062|Minimum Grade of C-|May be taken concurrently)
AND (MATH 1042|Minimum Grade of C-|May not be taken concurrently
OR MATH 1942|Minimum Grade of C-|May not be taken concurrently).

BIOE 3001. Research Design and Methods in Bioengineering. 2 Credit Hours.

In this course the upper division students will learn how to integrate fundamental principles of biology, chemistry, engineering, mathematics (including statistics) and physics to develop practical solutions for a variety of biomedical problems from cells to organisms. Students will use both engineering (methodology) and scientific (hypothesis) approaches to problem-solving thereby learning to distinguish between the two approaches. This course will teach the students the fundamental principles underlying modern measurements and control instrumentation utilized in science and engineering. Taking a quantitative and hands-on approach to measurement theory and practice, this course will present and analyze example instruments currently used in academic and industrial research. In addition, the students will consider and discuss bioethical issues involving biological and living systems. Specific bioethics topics that will be covered include stem cells, patents, conflict of interest, patient rights, animal rights, organ donation, and data manipulations but are not limited to them.

Department restrictions: Must be enrolled in one of the following Departments: Engineering:Bio Engineering
Field of Study Restrictions: Must be enrolled in one of the following Majors: Bioengineering

Repeatability: This course may not be repeated for additional credits

Pre-requisites:
(MATH 1041|Minimum Grade of C-|May not be taken concurrently
OR MATH 1941|Minimum Grade of C-|May not be taken concurrently
OR MATH 1038|Minimum Grade of C-|May not be taken concurrently)
AND (BIOL 1111|Minimum Grade of C-|May not be taken concurrently
OR BIOL 2112|Minimum Grade of C-|May not be taken concurrently
OR BIOL 1012|Minimum Grade of C-|May not be taken concurrently
OR BIOL 1911|Minimum Grade of C-|May not be taken concurrently
OR BIOL 2912|Minimum Grade of C-|May not be taken concurrently
OR CHEM 1031|Minimum Grade of C-|May not be taken concurrently
OR CHEM 1035|Minimum Grade of C-|May not be taken concurrently
OR CHEM 1951|Minimum Grade of C-|May not be taken concurrently).

BIOE 3101. BioE Lab #1 - Bioelectrical Engineering. 3 Credit Hours.

This laboratory class will introduce students to the empirical study of bioelectric phenomena in physiological systems. This includes the origin of biopotentials, the use of biopotential electrodes in their measurements and subsequent amplification, signal processing and analysis of their physiological relevance. Applications of physical principles and basic electric engineering techniques are emphasized.

Department restrictions: Must be enrolled in one of the following Departments: Engineering:Bio Engineering
Field of Study Restrictions: Must be enrolled in one of the following Majors: Bioengineering

Repeatability: This course may not be repeated for additional credits

Pre-requisites:
(BIOE 3201|Minimum Grade of C-|May be taken concurrently)
AND (PHYS 1062|Minimum Grade of C-|May not be taken concurrently
OR PHYS 2022|Minimum Grade of C-|May not be taken concurrently)
AND (MATH 1042|Minimum Grade of C-|May not be taken concurrently
OR MATH 1942|Minimum Grade of C-|May not be taken concurrently)
AND (BIOE 2001|Minimum Grade of C-|May be taken concurrently).

BIOE 3102. BioE Lab #2 - Biomaterials. 3 Credit Hours.

This laboratory class will teach students experimental methods used to prepare and characterize biomaterials used in biomedical engineering. Students will learn basic techniques for the fabrication and characterization tools used for polymeric biomaterials, and investigate structure-property relationships as it applies to thermal, mechanical, surface and morphological properties of polymeric biomaterials.

Department restrictions: Must be enrolled in one of the following Departments: Engineering:Bio Engineering
Field of Study Restrictions: Must be enrolled in one of the following Majors: Bioengineering

Repeatability: This course may not be repeated for additional credits

Pre-requisites:
BIOE 3101|Minimum Grade of C-|May not be taken concurrently.

BIOE 3201. Biomedical Instrumentation. 2 Credit Hours.

This course will introduce the upper division students to the fundamentals of medical instrumentation. Specifically, it will teach the physiological/physicochemical, biomechanical, computational and electronic principles governing the operation of select medical instrumentation. Focusing on classical and modern instrumentation used in specific clinical departments, such as cardiology, pulmonary medicine and critical care, radiology, and anesthesiology, the course will also introduce the students to the operation, safety aspects, and calibration of electronic, optical and acoustical instruments, as well as those involving ionizing radiation.

Department restrictions: Must be enrolled in one of the following Departments: Engineering:Bio Engineering
Field of Study Restrictions: Must be enrolled in one of the following Majors: Bioengineering

Repeatability: This course may not be repeated for additional credits

Pre-requisites:
(PHYS 1062|Minimum Grade of C-|May not be taken concurrently
OR PHYS 2022|Minimum Grade of C-|May not be taken concurrently)
AND (MATH 1042|Minimum Grade of C-|May not be taken concurrently
OR MATH 1942|Minimum Grade of C-|May not be taken concurrently).

BIOE 3301. Biomedical Signals and Systems. 3 Credit Hours.

This course will expose students to digital signal processing with emphasis on problems in biomedical research and clinical medicine. It covers principles and algorithms for processing signals and systems in both continuous and discrete time domains with examples from biomedical signal processing and control. Theory and practice of Continuous-time linear systems: convolution, steady-state responses, Fourier and Laplace transforms, transfer functions, poles and zeros, stability, sampling, feedback. Discrete-time linear systems: Z transform, filters, Fourier transform, signal processing. This class will make extensive use of Matlab projects.

Department restrictions: Must be enrolled in one of the following Departments: Engineering:Bio Engineering
Field of Study Restrictions: Must be enrolled in one of the following Majors: Bioengineering

Repeatability: This course may not be repeated for additional credits

Pre-requisites:
MATH 2101|Minimum Grade of C-|May not be taken concurrently
OR ENGR 2011|Minimum Grade of C-|May not be taken concurrently
OR MEE 2011|Minimum Grade of C-|May not be taken concurrently.

BIOE 3302. Drug Delivery. 3 Credit Hours.

This course will cover the engineering principles utilized in the design of drug delivery systems. Topics will include: drug delivery mechanisms (oral, parenteral, passive, targeted, etc.); therapeutic modalities and mechanisms of action; engineering principles of controlled release and quantitative understanding of drug transport (diffusion, convection); effects of electrostatics, macromolecular conformation, and molecular dynamics on interfacial interactions; thermodynamic principles of self-assembly; chemical and physical characteristics of delivery molecules and assemblies (polymer based, lipid based); significance of biodistributions and pharmacokinetic models; toxicity issues and immune responses.

Department restrictions: Must be enrolled in one of the following Departments: Engineering:Bio Engineering
Field of Study Restrictions: Must be enrolled in one of the following Majors: Bioengineering

Repeatability: This course may not be repeated for additional credits

Pre-requisites:
(CHEM 2201|Minimum Grade of C-|May not be taken concurrently)
AND (MATH 3041|Minimum Grade of C-|May be taken concurrently).

BIOE 3303. Biotransport Phenomena. 3 Credit Hours.

This course will provide students with a quantitative understanding of momentum transport (viscous flow) and mass transport (convection and diffusion) in living systems. The application of engineering methods to model and quantify aspects of bioengineering systems will be covered. Emphasis will be placed on the analysis of fluid flow phenomena in the cardiovascular and respiratory system as well as other human organ systems.

Department restrictions: Must be enrolled in one of the following Departments: Engineering:Bio Engineering
Field of Study Restrictions: Must be enrolled in one of the following Majors: Bioengineering

Repeatability: This course may not be repeated for additional credits

Pre-requisites:
(ENGR 3571|Minimum Grade of C-|May not be taken concurrently)
AND (CHEM 1031|Minimum Grade of C-|May not be taken concurrently
OR CHEM 1035|Minimum Grade of C-|May not be taken concurrently
OR CHEM 1951|Minimum Grade of C-|May not be taken concurrently)
AND (MATH 3041|Minimum Grade of C-|May be taken concurrently).

BIOE 3312. Mechanics for Bioengineering II. 4 Credit Hours.

This course will provide students with an understanding of the application of mechanics of solids and dynamics to engineering problem analyses. Topics will introduce basic concepts of dynamics and mechanics with application to physiologic loading and motion in the body.

Department restrictions: Must be enrolled in one of the following Departments: Engineering:Bio Engineering
Field of Study Restrictions: Must be enrolled in one of the following Majors: Bioengineering

Repeatability: This course may not be repeated for additional credits

Pre-requisites:
BIOE 2312|Minimum Grade of C-|May not be taken concurrently.

BIOE 3331. Principles of Macromolecular Science. 3 Credit Hours.

In this course students will gain an understanding of the fundamentals of polymer physical chemistry. We will cover polymer structure and conformation, bulk and solution thermodynamics and phase behavior, polymer networks, and viscoelasticity. We will also apply engineering principles to the analysis of biomacromolecules, such as proteins, polysaccharides and oligonucleotides. Upon the completion of the course, students should be able to understand the influence of monomer structure, temperature, solution conditions, degree of polymerization and 3D conformation on the function of biopolymers.

Department restrictions: Must be enrolled in one of the following Departments: Engineering:Bio Engineering
Field of Study Restrictions: Must be enrolled in one of the following Majors: Bioengineering

Repeatability: This course may not be repeated for additional credits

Pre-requisites:
CHEM 1032|Minimum Grade of C-|May not be taken concurrently
OR CHEM 1952|Minimum Grade of C-|May not be taken concurrently.

BIOE 3511. Interactions of Biomaterials with Living Tissues. 3 Credit Hours.

This course will cover topics that illustrate how biomaterials interact with living tissues, focusing on cell culture, immunology, cell-biomaterial interfaces, and cell signaling. The students will learn the fundamentals maintaining living cells in culture and how these cells react to the presence of biomaterials using lecture and laboratory format.

Department restrictions: Must be enrolled in one of the following Departments: Engineering:Bio Engineering
Field of Study Restrictions: Must be enrolled in one of the following Majors: Bioengineering

Repeatability: This course may not be repeated for additional credits

Pre-requisites:
(BIOE 2101|Minimum Grade of C-|May not be taken concurrently)
AND (CHEM 1031|Minimum Grade of C-|May not be taken concurrently
OR CHEM 1035|Minimum Grade of C-|May not be taken concurrently
OR CHEM 1951|Minimum Grade of C-|May not be taken concurrently).

BIOE 3719. Introduction to Bioengineering. 3 Credit Hours.

Course topics include biomaterials and implant materials, research proposal preparation, tyrosine-derived synthetic polymer devices for tissue engineering spine biomechanics, cellular material biomechanics, orthopedic biomechanics, hydroxyapatite/polymer composites, applications of injury biomechanics, biomechanics of the lower extremities, principles of polymers used in dental and biomaterials, interfaces in biomaterials. Students will be required to prepare a proposal for a design-oriented term project (i.e. rationale, concept and design, but no actual construction).

Class Restrictions: Must be enrolled in one of the following Classes: Junior 60 to 89 Credits, Senior 90 to 119 Credits, Senior/Fifth Year 120+ Credits
College Restrictions: Must be enrolled in one of the following Colleges: Engineering

Repeatability: This course may not be repeated for additional credits.

BIOE 3725. Cell Biology for Engineers. 3 Credit Hours.

Cell Biology for Engineers is a basic course that introduces biological concepts in modern cellular and molecular biology to engineering students. Topics will include the chemical composition of cells, bioenergetics and metabolism, structure and function of the plasma membrane, transport across membranes, the cytoplasmic membrane system, the extracellular matrix, interactions between cells and their environment, the cytoskeleton and cell motility, sensory systems, and cell signaling. In addition, an introduction to basic anatomy and physiology of vertebrates will include the skeletal system, muscle system, cardiovascular system, and nervous system.

College Restrictions: Must be enrolled in one of the following Colleges: Engineering

Repeatability: This course may not be repeated for additional credits

Pre-requisites:
CHEM 1031|Minimum Grade of C-|May not be taken concurrently
OR CHEM 1035|Minimum Grade of C-|May not be taken concurrently
OR CHEM 1951|Minimum Grade of C-|May not be taken concurrently.

BIOE 4101. BioE Lab #3 - Biomechanics. 3 Credit Hours.

In this course students will apply principles of engineering mechanics in the design and utilization of biomechanical instrumentation. Principles of transduction, mechanics, sampling theory, strain, temperature, and flow measurement as applied to biomechanical systems will be covered. A background in data acquisition, electrical safety, operational amplifier and bridge circuits, and measurements is provided. Students will investigate the biomechanics of the musculoskeletal and cardiovascular systems in normal and pathological states.

Department restrictions: Must be enrolled in one of the following Departments: Engineering:Bio Engineering
Field of Study Restrictions: Must be enrolled in one of the following Majors: Bioengineering

Repeatability: This course may not be repeated for additional credits

Pre-requisites:
BIOE 3102|Minimum Grade of C-|May not be taken concurrently.

BIOE 4278. Cardiac Devices. 3 Credit Hours.

Intended for electrical engineering, biology, and bioengineering students. No course prerequisites. This course will cover cardiac anatomy and physiology, the heart's electrical system in health and disease, cardiac ECG rhythm interpretation, design and function of ECG monitoring devices, pacemakers and external and implanted defibrillators, and arrhythmia detection algorithms. The course will include observation of pacemaker implants, and troubleshooting in a pacemaker follow-up clinic. The course will prepare students to take the Heart Rhythm Society Allied Professional Pacemaker Certification examination. It is intended to put students in a competitive advantage for getting jobs in the expanding pacemaker and other medical electronics device industries.

Repeatability: This course may not be repeated for additional credits.

BIOE 4301. Bioengineering Seminar. 1 Credit Hour.

This seminar is intended for bioengineering students who are interested in acquiring hands-on presentation skills and, in addition, keeping up-to-date with the bioengineering research fields. The aim of the class is to allow upper division students to present a summarized view of a specific bioengineering or biomedical engineering topic. Specific topics that will be suggested to be covered (by the students) are biomaterials, tissue/regenerative engineering, bioimaging, biosensing, bionanotechnology (or nanobiotechnology), neuroengineering, bioinformatics (computational), biomechanics, (but are not limited to them). Guest lecturers from academia and industry will be invited to talk on several occasions.

Department restrictions: Must be enrolled in one of the following Departments: Engineering:Bio Engineering
Field of Study Restrictions: Must be enrolled in one of the following Majors: Bioengineering
Class Restrictions: Must be enrolled in one of the following Classes: Junior 60 to 89 Credits, Senior 90 to 119 Credits, Senior/Fifth Year 120+ Credits

Repeatability: This course may not be repeated for additional credits

Pre-requisites:
BIOE 2001|Minimum Grade of C-|May not be taken concurrently.

BIOE 4311. The Entrepreneurial Bioengineer. 2 Credit Hours.

Recognizing the increasingly entrepreneurial landscape of Bioengineering, this course will introduce the students to the fundamentals of entrepreneurship and is designed to provide students with a working knowledge of the modern entrepreneurial and business planning and the regulatory process with the special focus on translational development of bioengineering products from the bench to the bedside.

Department restrictions: Must be enrolled in one of the following Departments: Engineering:Bio Engineering
Field of Study Restrictions: Must be enrolled in one of the following Majors: Bioengineering
Class Restrictions: Must be enrolled in one of the following Classes: Junior 60 to 89 Credits, Senior 90 to 119 Credits, Senior/Fifth Year 120+ Credits

Repeatability: This course may not be repeated for additional credits

Pre-requisites:
BIOE 2001|Minimum Grade of C-|May not be taken concurrently.

BIOE 4333. Applied Biospectroscopy. 3 Credit Hours.

This course introduces the basics of light propagation in tissue and other turbid media, vibrational spectroscopy, absorption and fluorescence, and emerging spectroscopic applications. Emphasis is on applications for assessment of biomolecules, engineered tissues and clinically-relevant analyses including musculoskeletal disease and cancer diagnosis. Multivariate analyses for complex spectral data sets will also be introduced.

Level Registration Restrictions: Must be enrolled in one of the following Levels: Undergraduate

Repeatability: This course may not be repeated for additional credits

Pre-requisites:
(MATH 2101|Minimum Grade of C-|May not be taken concurrently
OR ENGR 2011|Minimum Grade of C-|May not be taken concurrently
OR MEE 2011|Minimum Grade of C-|May not be taken concurrently)
AND (MATH 3041|Minimum Grade of C-|May not be taken concurrently)
AND (PHYS 1061|Minimum Grade of C-|May not be taken concurrently)
AND (CHEM 1031|Minimum Grade of C-|May not be taken concurrently
OR CHEM 1035|Minimum Grade of C-|May not be taken concurrently
OR CHEM 1951|Minimum Grade of C-|May not be taken concurrently)
AND (BIOL 1111|Minimum Grade of C-|May not be taken concurrently
OR BIOL 2112|Minimum Grade of C-|May not be taken concurrently
OR BIOL 1012|Minimum Grade of C-|May not be taken concurrently
OR BIOL 1911|Minimum Grade of C-|May not be taken concurrently
OR BIOL 2912|Minimum Grade of C-|May not be taken concurrently).

BIOE 4411. Capstone Elective: Biomaterials. 3 Credit Hours.

This course will focus on materials and design parameters used to develop human implant devices, bulk and surface characterization methods for biomaterials, biocompatibility, failure mechanisms of current biomaterials, and regulatory requirements for design and testing of human implant devices. Special attention will be given to biomaterials used in tissue regeneration, orthopedics, and controlled drug delivery.

Department restrictions: Must be enrolled in one of the following Departments: Engineering:Bio Engineering
Field of Study Restrictions: Must be enrolled in one of the following Majors: Bioengineering

Repeatability: This course may not be repeated for additional credits

Pre-requisites:
(BIOE 2101|Minimum Grade of C-|May not be taken concurrently)
AND (CHEM 2201|Minimum Grade of C-|May not be taken concurrently).

BIOE 4421. Capstone Elective: Bionanotechnology. 3 Credit Hours.

This course is intended for upper division students interested in acquiring knowledge involving nanometer-sized objects frequently utilized within the biomedical sciences and engineering areas. The aim of the class is to introduce fundamental concepts critical in the design, preparation, analysis, and usage of bionanotechnology (or nanobiotechnology) and its multiple bottom-up and top-down approaches. Multiple nanomaterials categories, such as nanoparticles, nanotubes, biomacromolecules, synthetic polymers, and self-assembled structures, will be covered in detail along with their applications.

Repeatability: This course may not be repeated for additional credits

Pre-requisites:
(CHEM 2201|Minimum Grade of C-|May not be taken concurrently)
AND (BIOE 1301|Minimum Grade of C-|May not be taken concurrently).

BIOE 4431. Capstone Elective: Neuroengineering. 3 Credit Hours.

This course will teach students how signals are generated and propagated in neurons and neuronal circuits, and how this knowledge can be utilized to engineer devices to assist people with neurologic disease or injury. The functions of neurons as discrete elements and as parts of neuronal assemblies will be examined; generator and action potentials; conduction in nerve fibers and across synaptic junctions; analysis of sensory and neuromuscular systems; EEG and EKG waveforms. At the completion of the course, students will have gained a fundamental understanding of neural interface/prosthetics design parameters from basic neural physiology to models of neural mechanisms. We will also review advanced neural interfaces currently being developed and or produced commercially by the field.

Department restrictions: Must be enrolled in one of the following Departments: Engineering:Bio Engineering
Field of Study Restrictions: Must be enrolled in one of the following Majors: Bioengineering

Repeatability: This course may not be repeated for additional credits

Pre-requisites:
(BIOE 2101|Minimum Grade of C-|May not be taken concurrently)
AND (MATH 3041|Minimum Grade of C-|May be taken concurrently).

BIOE 4441. Capstone Elective: Biomechanics. 3 Credit Hours.

This course will provide students with an understanding of the mechanics of cells, tissue, and organ systems as well as methods for their analysis. Topics will include motion-actuating, force generating, and load-supporting mechanisms in the musculoskeletal system, as explained from basic engineering principles. We will also cover experimental and analytical approaches to designing load bearing implants and prosthetic devices.

Department restrictions: Must be enrolled in one of the following Departments: Engineering:Bio Engineering
Field of Study Restrictions: Must be enrolled in one of the following Majors: Bioengineering
College Restrictions: Must be enrolled in one of the following Colleges: Engineering

Repeatability: This course may not be repeated for additional credits

Pre-requisites:
(BIOE 2101|Minimum Grade of C-|May not be taken concurrently
OR BIOE 3725|Minimum Grade of C-|May not be taken concurrently)
AND (BIOE 3312|Minimum Grade of C-|May not be taken concurrently
OR (ENGR 2332|Minimum Grade of C-|May not be taken concurrently
AND ENGR 2333|Minimum Grade of C-|May not be taken concurrently)).

BIOE 4451. Capstone Elective: Biomedical Imaging. 3 Credit Hours.

In this course students learn how light, X-rays, radiopharmaceuticals, ultrasound, magnetic fields, and other energy probes are generated and how they interact with tissues and detectors to produce useful image contrast. Practical issues such as beam generation, dose limitations, patient motion, spatial resolution and dynamic range limitations, and cost-effectiveness will be addressed. Emphasis will be placed on diagnostic radiological imaging physics, including the planar X-ray, digital subtraction angiography mammography, computed tomography, nuclear medicine, ultrasound, and magnetic resonance imaging modalities.

Department restrictions: Must be enrolled in one of the following Departments: Engineering:Bio Engineering
Field of Study Restrictions: Must be enrolled in one of the following Majors: Bioengineering

Repeatability: This course may not be repeated for additional credits

Pre-requisites:
(PHYS 1062|Minimum Grade of C-|May not be taken concurrently)
AND (CHEM 1031|Minimum Grade of C-|May not be taken concurrently
OR CHEM 1035|Minimum Grade of C-|May not be taken concurrently
OR CHEM 1951|Minimum Grade of C-|May not be taken concurrently)
AND (BIOL 1111|Minimum Grade of C-|May not be taken concurrently
OR BIOL 1012|Minimum Grade of C-|May not be taken concurrently
OR BIOL 2112|Minimum Grade of C-|May not be taken concurrently
OR BIOL 1911|Minimum Grade of C-|May not be taken concurrently
OR BIOL 2912|Minimum Grade of C-|May not be taken concurrently)
AND (MATH 3041|Minimum Grade of C-|May not be taken concurrently).

BIOE 4461. Capstone Elective: Principles of Tissue and Regenerative Engineering. 3 Credit Hours.

This course will introduce fundamental concepts of tissue engineering and regenerative medicine, focusing on biomaterials used for scaffolds, mechanisms of cell-biomaterial interactions, biocompatibility and foreign body response, cellular engineering, and tissue biomechanics. Principles of cell/developmental and stem cell biology will be introduced, which will enable the students to apply a multidisciplinary approach to engineering select tissues and organs, such as the musculoskeletal system, cardiovascular tissues, the nervous system, and to design artificial organs. These topics will also be discussed in the context of scale-up, manufacturing, ethical and regulatory concerns.

Department restrictions: Must be enrolled in one of the following Departments: Engineering:Bio Engineering
Field of Study Restrictions: Must be enrolled in one of the following Majors: Bioengineering

Repeatability: This course may not be repeated for additional credits

Pre-requisites:
(BIOE 2101|Minimum Grade of C-|May not be taken concurrently)
AND (CHEM 2202|Minimum Grade of C-|May not be taken concurrently).

BIOE 4500. Special Topics in Bioengineering. 3 Credit Hours.

An emerging or advanced area of bioengineering research will be covered. Topics vary by semester.

Field of Study Restrictions: Must be enrolled in one of the following Fields of study: Bioengineering

Repeatability: This course may be repeated for additional credit..

BIOE 4501. Regenerative Engineering. 3 Credit Hours.

This course is a continuation of fundamental concepts introduced in Principles of Tissue and Regenerative Engineering focusing on developmental biology used in tissue engineering and regenerative medicine. Principles of cell development/biology, cell-cell interactions, signal transduction, and stem cell biology will be discussed with applications to regenerative medicine. These topics will also be discussed in the context of scale-up, manufacturing, ethical and regulatory concerns.

Department restrictions: Must be enrolled in one of the following Departments: Engineering:Bio Engineering
Field of Study Restrictions: Must be enrolled in one of the following Majors: Bioengineering
Class Restrictions: Must be enrolled in one of the following Classes: Senior 90 to 119 Credits, Senior/Fifth Year 120+ Credits

Repeatability: This course may not be repeated for additional credits

Pre-requisites:
BIOE 4461|Minimum Grade of C-|May not be taken concurrently.

BIOE 4555. Capstone Elective - Biophotonics: Seeing is Believing. 3 Credit Hours.

Only a small portion of the world around us is visible to the human eye. So, is there a way to visualize chaos, force, fractals, viral infection or cancer metastasis? Once we see biology happen, is the result a pretty image or a valuable measurement? Can the light be used to modify biological processes? In this course students will learn how photons are used to visualize and manipulate biomaterials at multiple scales. The first part of the course will provide a review of electromagnetism, light and optics. We will cover typical hardware used for imaging in biology, such as light sources, objectives and detectors used to generate images. Next, chemistry of imaging probes will be covered, including photochemistry and interaction of light and matter. The rest of the course will give a comprehensive overview of methodologies for multiscale imaging in life sciences, ranging from electron to atomic-molecular-cell-multicellular tissue-whole body scales, in vitro and in vivo. This will include among others Spectroscopy, Microscopy (Electron, Atomic, Fluorescent), Flow Cytometry, Optical Traps, Bioluminescence, X-Ray, MRI. Final classes will include special demonstrations in the imaging labs in the Temple Main Campus.

Field of Study Restrictions: Must be enrolled in one of the following Fields of study: Bioengineering

Repeatability: This course may not be repeated for additional credits

Pre-requisites:
(PHYS 1062|Minimum Grade of C-|May not be taken concurrently
OR PHYS 2022|Minimum Grade of C-|May not be taken concurrently)
AND (CHEM 2202|Minimum Grade of C-|May not be taken concurrently)
AND (BIOL 2112|Minimum Grade of C-|May not be taken concurrently
OR BIOE 3102|Minimum Grade of C-|May be taken concurrently).

BIOE 4741. Biomaterials for Engineers. 3 Credit Hours.

This course introduces engineering students to materials as they interact with biological systems, primarily in medicine. Topics will include a review of properties of materials, the classes of materials, tissues that come into contact with materials, the degradation of materials in the biological environment, the application of materials for specific uses, tissue engineering, and biomaterials standards and regulations.

Field of Study Restrictions: May not be enrolled in one of the following Majors: Bioengineering
Class Restrictions: Must be enrolled in one of the following Classes: Junior 60 to 89 Credits, Senior 90 to 119 Credits, Senior/Fifth Year 120+ Credits

Repeatability: This course may not be repeated for additional credits

Pre-requisites:
CHEM 1031|Minimum Grade of C-|May not be taken concurrently
OR CHEM 1035|Minimum Grade of C-|May not be taken concurrently
OR CHEM 1951|Minimum Grade of C-|May not be taken concurrently.