This course will cover the basic concepts of protein structure analysis, with focus on database searching and molecular modeling techniques. A broad qualitative overview of macromolecular structure and protein folding will be provided before addressing the issues of sequence alignment, secondary structure calculation, and tertiary structure prediction. The course will also cover few selected advanced topics such as prediction of quaternary structure, Hidden Markov Models, and other approaches for building probabilistic models of sequence ensembles. Computer-based activities will allow students to develop a strong familiarity with molecular visualization software and web-based tools.
Level Registration Restrictions: Must be enrolled in one of the following Levels: Graduate.
Repeatability: This course may not be repeated for additional credits.