Bioengineering (BIOE)

Courses

BIOE 5301. Biosignals. 3 Credit Hours.

This course offers a deep overview of the signals in the Biomedical fields. Signals are studied in several modalities, including time frame, frequency frame, and statistical frame. A deep analysis of filters and analysis tools is included together with some basic techniques of storing and pattern interpretation techniques. Furthermore, the course gives to the student the necessary knowledge to realize a complete Data Acquisition, Analysis and Logging using LabView as a tool. The laboratory activities include the development of a complete system to do acquisition, analysis, report and logging of data incoming from sensors.

Level Registration Restrictions: Must be enrolled in one of the following Levels: Graduate

Repeatability: This course may not be repeated for additional credits.

BIOE 5311. Entrepreneurial Studies in Regenerative Medicine - From Idea to Medical Practice. 3 Credit Hours.

This course provides a practical overview of all stages of development of medical devices in regenerative medicine, from idea to launch of a company and commercialization of the product into international markets to address unmet medical needs. We will review the initial idea, based on an unmet medical need, review issues of intellectual property creation, determination of target markets, pre-clinical and clinical development, and different regulatory pathways leading to product approval and market introduction. We will discuss issues of company formation, financing and management, as well as target markets and avenues towards revenue generation.

Level Registration Restrictions: Must be enrolled in one of the following Levels: Graduate

Repeatability: This course may not be repeated for additional credits.

BIOE 5321. Biosensors. 3 Credit Hours.

This course offers an in-depth overview of several sensors used in the Biomedical Fields. The sensors are analyzed from an engineering point of view going from the physical principles to the necessary filtering and linearization studying the characteristics of output signals. The course also gives the student the necessary basis for Data Acquisition using LabView as a tool. The laboratory activities include the connection of sensors, the study of amplification, linearization and interpretation of data.

Level Registration Restrictions: Must be enrolled in one of the following Levels: Graduate

Repeatability: This course may not be repeated for additional credits.

BIOE 5333. Applied Biospectroscopy. 3 Credit Hours.

This course introduces the basics of light propagation in tissue and other turbid media, vibrational spectroscopy, absorption and fluorescence, and emerging spectroscopic applications. Emphasis is on applications for assessment of biomolecules, engineered tissues and clinically-relevant analyses including musculoskeletal disease and cancer diagnosis. Multivariate analyses for complex spectral data sets will also be introduced.

Level Registration Restrictions: Must be enrolled in one of the following Levels: Graduate

Repeatability: This course may not be repeated for additional credits.

BIOE 5421. Capstone Elective: Bionanotechnology. 3 Credit Hours.

This course is intended for graduate students interested in acquiring knowledge involving nanometer-sized objects frequently utilized within the biomedical sciences and engineering areas. The aim of the class is to introduce fundamental concepts critical in the design, preparation, analysis, and usage of bionanotechnology (or nanobiotechnology) and its multiple bottom-up and top-down approaches. Multiple nanomaterials categories, such as nanoparticles, nanotubes, biomacromolecules, synthetic polymers, and self-assembled structures, will be covered in detail along with their applications.

Department restrictions: Must be enrolled in one of the following Departments: Engineering:Bio Engineering
Field of Study Restrictions: Must be enrolled in one of the following Majors: Bioengineering
Level Registration Restrictions: Must be enrolled in one of the following Levels: Graduate

Repeatability: This course may not be repeated for additional credits.

BIOE 5431. Neuroengineering. 3 Credit Hours.

This course will teach students how signals are generated and propagated in neurons and neuronal circuits, and how this knowledge can be utilized to engineer devices to assist people with neurologic disease or injury. The functions of neurons as discrete elements and as parts of neuronal assembles will be examined; generator and action potentials; conduction in nerve fibers and across synaptic junctions; analysis of sensory and neuromuscular systems; EEG and EKG waveforms. At the completion of the course, students will have gained a fundamental understanding of neural interface/prosthetics design parameters from basic neural physiology to models of neural mechanisms. We will also review advanced neural interfaces currently being developed. The course will end with coverage of selected frontiers of neuroscience, including neurogenetic techniques, viral methods, and optogenetics.

Level Registration Restrictions: Must be enrolled in one of the following Levels: Graduate

Repeatability: This course may not be repeated for additional credits.

BIOE 5441. Biomechanics. 3 Credit Hours.

Prerequisites: [BIOE 2101 (Engineering Principles of Physiological Systems) with a minimum grade of C-, or BIOE 5737 (Systems Physiology for Engineers) with a minimum grade of B-, or equivalent course] and [BIOE 2312 (Mechanics for Bioengineering I) with a minimum grade of C-, or {ENGR 2331 (Engineering Statics) with a minimum grade of C- and ENGR 2333 (Mechanics of Solids) with a minimum grade of C-}, or equivalent course] and [BIOE 3312 (Mechanics for Bioengineering II) with a minimum grade of C-, or ENGR 2332 (Engineering Dynamics) with a minimum grade of C-, or equivalent course]

This course will provide students with an understanding of the mechanics of cells, tissue, and organ systems as well as methods for their analyses. Topics will include motion-actuating, force generating, and load-supporting mechanisms in the musculoskeletal system, as explained from basic engineering principles. We will also cover experimental and analytical approaches to designing load bearing implants and prosthetic devices.

Level Registration Restrictions: Must be enrolled in one of the following Levels: Graduate
College Restrictions: Must be enrolled in one of the following Colleges: Engineering

Repeatability: This course may not be repeated for additional credits.

BIOE 5451. Biomedical Imaging. 3 Credit Hours.

This course focuses on principles of diagnostic radiological imaging physics, including X-ray, computed tomography, and nuclear medicine, as well as optical imaging, ultrasound and magnetic resonance imaging modalities. The interaction of these modalities with tissues and detectors to produce useful image contrast will be presented, and students will gain an understanding of the basic physics of image acquisition and algorithms for image generation. Signal and noise characteristics, image quality and image reconstruction algorithms will also be covered. Image processing through MATLAB programming will be covered in class and in assignments.

Level Registration Restrictions: Must be enrolled in one of the following Levels: Graduate

Repeatability: This course may not be repeated for additional credits.

BIOE 5461. Principles of Tissue and Regenerative Engineering. 3 Credit Hours.

This course will introduce fundamental concepts of tissue engineering and regenerative medicine, focusing biomaterials used for scaffolds, mechanisms of cell-biomaterial interactions, biocompatibility and foreign body response, cellular engineering, and tissue biomechanics. Principles of cell/developmental and stem cell biology will be introduced, which will enable the students to apply a multidisciplinary approach to engineering select tissues and organs, such as the musculoskeletal system, cardiovascular tissues, the nervous system, and to design artificial organs. These topics will also be discussed in the context of scale-up, manufacturing, ethical and regulatory concerns.

Level Registration Restrictions: Must be enrolled in one of the following Levels: Graduate

Repeatability: This course may not be repeated for additional credits.

BIOE 5500. Special Topics in Bioengineering. 3 Credit Hours.

An emerging or advanced area of bioengineering research will be covered. Topics vary by semester.

Level Registration Restrictions: Must be enrolled in one of the following Levels: Graduate

Repeatability: This course may be repeated for additional credit..

BIOE 5501. Regenerative Engineering. 3 Credit Hours.

This course is a continuation of fundamental concepts introduced in Principles of Tissue and Regenerative Engineering focusing on developmental biology used in tissue engineering and regenerative medicine. Principles of cell development/biology, cell-cell interactions, signal transduction, and stem cell biology will be discussed with applications to regenerative medicine. These topics will also be discussed in the context of scale-up, manufacturing, ethical and regulatory concerns.

Department restrictions: Must be enrolled in one of the following Departments: Engineering:Bio Engineering
Field of Study Restrictions: Must be enrolled in one of the following Majors: Bioengineering
Level Registration Restrictions: Must be enrolled in one of the following Levels: Graduate

Repeatability: This course may not be repeated for additional credits

Pre-requisites:
(BIOE 5461|Minimum Grade of B-|May not be taken concurrently)
AND (BIOE 5721|Minimum Grade of B-|May not be taken concurrently).

BIOE 5555. Biophotonics: Seeing is Believing. 3 Credit Hours.

Only a small portion of the world around us is visible to the human eye. So, is there a way to visualize chaos, force, fractals, viral infection or cancer metastasis? Once we see biology happen, is the result a pretty image or a valuable measurement? Can the light be used to modify biological processes? In this course students will learn how photons are used to visualize and manipulate biomaterials at multiple scales. The first part of the course will provide a review of electromagnetism, light and optics. We will cover typical hardware used for imaging in biology, such as light sources, objectives and detectors used to generate images. Next, chemistry of imaging probes will be covered, including photochemistry and interaction of light and matter. The rest of the course will give a comprehensive overview of methodologies for multiscale imaging in life sciences, ranging from electron to atomic-molecular-cell-multicellular tissue-whole body scales, in vitro and in vivo. This will include among others Spectroscopy, Microscopy (Electron, Atomic, Fluorescent), Flow Cytometry, Optical Traps, Bioluminescence, X-Ray, MRI. Final classes will include special demonstrations in the imaging labs in the Temple Main Campus.

Field of Study Restrictions: Must be enrolled in one of the following Fields of study: Bioengineering
Level Registration Restrictions: Must be enrolled in one of the following Levels: Graduate

Repeatability: This course may not be repeated for additional credits.

BIOE 5719. Introduction to Bioengineering. 3 Credit Hours.

This course offers an introduction to biomedical engineering, a diverse and evolving field that integrates engineering principles, life sciences, clinical medicine, research and engineering design, with the overall goal of improving health care and quality of life. Professors with expertise in specific fields of biomedical engineering will present lectures and discussions on a broad range of topics, including tissue engineering and regenerative medicine, biomaterials, biomechanics, bioinstrumentation, biomedical imaging and optics, and signal processing.

Level Registration Restrictions: Must be enrolled in one of the following Levels: Graduate

Repeatability: This course may not be repeated for additional credits.

BIOE 5721. Cell Biology for Engineers. 3 Credit Hours.

This course introduces biological concepts in modern cellular and molecular biology to engineering students. Topics will include the chemical composition of cells, bioenergetics and metabolism, structure and function of the plasma membrane, transport across membranes, the cytoplasmic membrane system, the extracellular matrix, interactions between cells and their environment, the cytoskeleton and cell motility, sensory systems, and cell signaling. In addition, an introduction to basic anatomy and physiology of vertebrates will include the skeletal system, muscle system, cardiovascular system, and nervous system.

Level Registration Restrictions: Must be enrolled in one of the following Levels: Graduate

Repeatability: This course may not be repeated for additional credits.

BIOE 5737. Systems Physiology for Engineers. 3 Credit Hours.

Systems Physiology is designed for graduate students majoring in engineering and for others interested in studying physiological processes from the molecular level to the organ/systems level. Among the topics covered are: scaling, respiration, circulation, cardiac process, renal function, muscle function, neuromuscular junction, neural processes, and temperature regulation. The course stresses the application of energetic and informational principles to the study of the body.

Level Registration Restrictions: Must be enrolled in one of the following Levels: Graduate

Repeatability: This course may not be repeated for additional credits.

BIOE 5741. Biomaterials for Engineers. 3 Credit Hours.

This course introduces engineering students to materials as they interact with biological systems, primarily in medicine. Topics will include a review of properties of materials, the classes of materials, tissues that come into contact with materials, the degradation of materials in the biological environment, the application of materials for specific uses, tissue engineering, and biomaterials standards and regulations.

Level Registration Restrictions: Must be enrolled in one of the following Levels: Graduate

Repeatability: This course may not be repeated for additional credits.

BIOE 9182. Independent Study. 1 to 6 Credit Hour.

Level Registration Restrictions: Must be enrolled in one of the following Levels: Graduate

Repeatability: This course may be repeated for additional credit..

BIOE 9282. Independent Study II. 3 Credit Hours.

Special study in a particular aspect of engineering under the direct supervision of a graduate faculty member. May be taken once by Ph.D. students.

Level Registration Restrictions: Must be enrolled in one of the following Levels: Graduate

Repeatability: This course may be repeated for additional credit..

BIOE 9991. Directed Research. 1 to 3 Credit Hour.

Level Registration Restrictions: Must be enrolled in one of the following Levels: Graduate

Repeatability: This course may be repeated for additional credit..

BIOE 9994. BioEngineering Preliminary Examination Preparation. 1 to 6 Credit Hour.

Level Registration Restrictions: Must be enrolled in one of the following Levels: Graduate

Repeatability: This course may be repeated for additional credit..

BIOE 9995. BioEngineering Project Research. 1 to 6 Credit Hour.

Level Registration Restrictions: Must be enrolled in one of the following Levels: Graduate

Repeatability: This course may be repeated for additional credit..

BIOE 9996. BioEngineering Thesis Research. 1 to 6 Credit Hour.

Level Registration Restrictions: Must be enrolled in one of the following Levels: Graduate

Repeatability: This course may be repeated for additional credit..

BIOE 9998. Bioengineering Pre-Dissertation Research. 1 to 6 Credit Hour.

Level Registration Restrictions: Must be enrolled in one of the following Levels: Graduate

Repeatability: This course may be repeated for additional credit..

BIOE 9999. BioEngineering Dissertation Research. 1 to 6 Credit Hour.

Level Registration Restrictions: Must be enrolled in one of the following Levels: Graduate

Repeatability: This course may be repeated for additional credit..